A new study from researchers in the South Korea indicates that pre-conditioned mesenchymal stem cells (MSCs) may be the best option for tissue regeneration and helping patients to recover from a stroke. The study was recently published in the journal Nature and may help scientists develop more effective stem cell treatments in the future.
The study was led by Dr. Ji Yong Lee, from the Institute for BioMedical Convergences at the Catholic Kwandong University International St. Mary’s Hospital in South Korea.
Previous studies have shown that the regenerative capacity of transplanted stem cells can treat conditions that affect the central nervous system, including ischemic stroke. This study has identified the individuals components of mesenchymal stem cells which are most beneficial for the regeneration of tissue after a stroke.
The authors of the paper said of the findings: “We and other groups have shown that in animal models MSCs can improve functional deficits induced by ischemic stroke. The therapeutic benefits are evident within days of cellular injection.”
They researchers continued, saying: “Recent studies on MSCs have shown that the secretome, exosome, and microvesicle (MV) fractions of conditioned media mimic the beneficial effects of MSCs.” They investigated whether MSC-MVs and MVs that were isolated from MSCs would improve functional recovery and tissue regeneration in a rats that had suffered a stroke.
The researchers discovered that preconditioned mesenchymal stem cells improved the neurological function of both normal and stroke-injured brains. They cited the improvements of brain function as evidence that MSC transplants promotes endogenous neurogenesis and corrects the effects of ischemic stroke.
The research suggests that the MVs/exosomes derived from MSCs can achieve excellent outcomes for stroke-affected brains.
Source: Stem Cells Could Improve Stroke Recovery, Study Finds
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